MDS is a bone marrow failure disorder. View Google Map Directions. How long does Vidaza work? This topic has 1 reply, 2 voices, and was last updated 5 years, 12 months ago by Site Admin.
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You must be logged in to reply to this topic. Keep me signed in. Researchers are exploring which factors might be useful for predicting a good outcome in patients with MDS. Certain treatment decisions for patients with MDS are based on cytogenetics, i.
Azacitidine is appropriate for patients with higher risk MDS who often have mutations in chromosome 7 or three or more abnormalities in their chromosomes. However this happens in only a small proportion of patients. Several ongoing efforts, including the HARMONY study, have a good chance of identifying more factors that predict azacitidine outcomes in MDS and other blood cancers and of predicting the effects of treatment on the patient's quality of life, healthcare costs, and care strategies.
The combination of Azacitidine and vorinostat seemed promising. These responses lasted an average of 16 months. Similarly, response rates and duration of response were promising in a phase I-II clinical trial of the combination of lenalidomide and azacitidine for higher-risk MDS. Fenaux added that studies are also evaluating combinations of Azacitidine with other treatments, such as valproic acid, venetoclax, immune checkpoint inhibitors, and idarubicin for higher-risk MDS or CMML.
Other research is assessing more intensive hypomethylating treatments or lower doses for longer use. Studies are testing different drugs, including venetoclax, cenersen, and a day decitabine cycle another hypomethylating agent for MDS with TP53 mutations.
Sekeres concluded that azacitidine alone is still the standard treatment for higher-risk MDS. But some evidence hints at better and more long-lasting responses for combination treatments if patients stay on them long enough. Are Vidaza and Azacitidine the same drug? Why does it have two names? Vidaza and Azacitidine are the same drug Azacitidine is the official generic and non-proprietary name given to the drug active ingredient while Vidaza is its trade name. Is Azacitidine Vidaza a chemotherapy?
How does Azacitidine work? How is Azacitidine administered? The schedule can be a bit demanding with 7 days of treatment per cycle plus clinics, blood tests and bone marrow biopsies adding up to some visits over the year. There are side effects to the treatment but after the first 3 cycles they have been reasonably tolerable. There was just one cycle in September which was particularly bad to the point that I was unable to complete the treatment but I have been OK since.
Overall I am very lucky that the treatment has worked for me and the price in frequency of hospital visits and side effects is small compared to the big improvement in quality of life it has given me. I do not know how long I will continue in remission but my consultant encourages me that new treatments unspecified are coming along in that event.
None of us know what is round the next corner -we just have to try and make the best of the hand we have been dealt. I should say though that when I was first diagnosed I had some difficulty coming to terms with it but a few sessions with a Macmillan counsellor did help ease my mind. I hope my account helps those of you who are about to start treatment or are finding it hard going. Best wishes to all for Xmas and the New Year. Re: David - an update after a year of Vidaza Azacitidine Post by janetstanford » Sun Dec 18, pm Hello David i am so pleased to read your good news so glad the treatment has worked for you and i am impressed visits to the hospital and regular bi-ops how brave i do admire you as you know we are all different and can react to the same drug in different ways good to hear the positive and new drugs i do hope so i am low risk so i do not have treatment as such just this "active monitoring" as Chris would say and blood transfusions i have approx 13 a year which pales to your 20 i have 2 units for 3 then i have 3 units every 4th i have concluded this is due to the age of blood cell ect It's good to hear Vidaza is working for you and even more encouraging about the future treatments.
I hope you have a lovely Christmas and that continues to see an improvement for you. Take care, and Janet Jan RAEB. Feb - 2 lots of chemo each weeks in hospital to destroy leukaemic cells resulting in remission from AML. July 6 - Stem cell transplant Doing very well, feel great Age Re: David - an update after a year of Vidaza Azacitidine Post by chris » Wed Dec 21, pm Hi David That is such wonderful news and thanks so much for posting it as it will be so encouraging to anybody considering this treatment.
Also interested to hear of counselling you received from a Macmillan counsellor as that was a service I wasn't aware of and it might help others recently diagnosed.
Yes, I expect the treatment must be quite restricting but the main thing is that you are well and not receiving transfusions - and you've managed some short breaks away too so all good. Keep well and all the best for F Age 71 MDS diagnosed in Sub-type CMML-1 but with anomalies! Normal-ish red cells, low white cells and platelets, slightly raised monocytes. Enlarged spleen. No current treatment - active monitoring 3-monthly.
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